Description
Product Characteristics:
E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:23685075, PubMed:25132172, PubMed:25578875). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity).
Subcellular location: Cytoplasm, Nucleus
Synonyms: RNF160, ZNF294, C21orf10, C21orf98, E3 ubiquitin-protein ligase listerin, RING finger protein 160, Zinc finger protein 294, LTN1, KIAA0714, HSPC087
Target Information: Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]